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Title 

Inhibitory activity of diarylheptanoids on farnesyl protein transferase

Authors 

Hyun Mi KangKwang Hee SonD C YangDong Cho HanJong Han KimN I BaekByoung-Mog Kwon

Publisher 

Taylor & Francis

Issue Date 

2004

Citation 

Natural Product Research, vol. 18, no. 4, pp. 295-299

Keywords 

alnus japonicacurcuma longadiarylheptanoidsfarnesyl protein transferaseprotein farnesyltransferaseprotein farnesyltransferase inhibitoralkyl and aryl transferasesinhibitory concentration 50

Abstract 

Diarylheptanoids [curcumin (1), demethoxycurcumin (2), bisdemethoxycurcumin (3), bisdimethoxymethylcurcumin (4), and 1,2-dihydrobis(de-O-methyl)curcumin (5)] were isolated from the methanolic extract of Curcuma longa L. and a new cyclic diarylheptanoid (6) and a known Compound 7 were isolated from fruits of Alnus japonica Steud. Diarylheptanoids (1-3) inhibited farnesyl protein transferase (FPTase) with an IC50 of 29-50 μM. The other compounds very mildly inhibited FPTase, therefore, the inhibitory activity on FPTase very much depends on the structure of diarylheptanoids.

ISSN 

1478-6419

Link 

http://dx.doi.org/10.1080/14786410310001620691

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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