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Title 

Relationship between flavonoid structure and inhibition of farnesyl protein transferase

Authors 

Hyun Mi KangJong Han KimMi Young LeeKwang Hee SonD C YangN I BaekByoung-Mog Kwon

Publisher 

Taylor & Francis

Issue Date 

2004

Citation 

Natural Product Research, vol. 18, no. 4, pp. 349-356

Keywords 

cell proliferation assayfarnesyl protein transferaseflavonoidstructure-activity relationshipprotein farnesyltransferasecancer inhibitiondrug structureenzyme inhibitiongrowth inhibition

Abstract 

Flavonoids are well-known phytochemicals that are produced by various plants in high quantities. The chemopreventive activity of flavonoids is dependent on their structural features. The studies of structure-FPTase inhibitory activity indicated that the number, position and substitution of hydroxyl groups of the A and B rings of flavonoid, and unsaturation of the C2-C3 bond are important factors affecting inhibition on FPTase by flavonoids. A couple of flavonoids inhibited FPTase and also the growth of human tumor cell lines, especially butein, which strongly inhibited the growth of colon cancer cell line (HCT116). However, flavanones and flavanols did not inhibit FPTase nor the growth of tumor cells.

ISSN 

1478-6419

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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