상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

DNA sequence and comparative analysis of chimpanzee chromosome 22

Authors 

H WatanabeA FujiyamaM HattoriYong Seok LeeJ E CheongSang-Haeng ChoiN SaitouHong-Seog ParkS Y WangM L YaspoY Sakaki

Publisher 

Nature Publishing Group

Issue Date 

2004

Citation 

Nature, vol. 429, no. 6990, pp. 382-388

Keywords 

chromosomesDNAamino acid sequencechromosome 21chromosome 22chromosome analysiscomparative studyDNA sequencephysical chromosome mappingrepetitive sequences, nucleic Acid

Abstract 

Human-chimpanzee comparative genome research is essential for narrowing down genetic changes involved in the acquisition of unique human features, such as highly developed cognitive functions, bipedalism or the use of complex language. Here, we report the high-quality DNA sequence of 33.3 megabases of chimpanzee chromosome 22. By comparing the whole sequence with the human counterpart, chromosome 21, we found that 1.44% of the chromosome consists of single-base substitutions in addition to nearly 68,000 insertions or deletions. These differences are sufficient to generate changes in most of the proteins. Indeed, 83% of the 231 coding sequences, including functionally important genes, show differences at the amino acid sequence level. Furthermore, we demonstrate different expansion of particular subfamilies of retrotransposons between the lineages, suggesting different impacts of retrotranspositions on human and chimpanzee evolution. The genomic changes after speciation and their biological consequences seem more complex than originally hypothesized.

ISSN 

0028-0836

Link 

http://dx.doi.org/10.1038/nature02564

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)