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Title 

Human ACAT-1 and -2 inhibitory activities of saucerneol B, manassantin A and B isolated from Saururus chinensis

Authors 

Woo Song LeeDae Woo LeeYoung Il BaekSo Jin AnKyung Hyun ChoYang Kyu ChoiHyoung-Chin KimHo Yong ParkK H BaeTae Sook Jeong

Publisher 

Elsevier

Issue Date 

2004

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 14, no. 12, pp. 3109-3112

Keywords 

hACAT-1 and hACAT-2hypocholesterolemic activityinhibitorlignansS. chinensismanassantin Amanassantin Bmethanol derivativeplant extractsaucerneol b

Abstract 

The sesquineolignan, saucerneol B (1), and dineolignans, manassantin A (2), and manassantin B (3), were isolated from the methanol extracts of Saururus chinensis root and elucidated by their spectroscopic data analysis. Compounds 1-3 inhibited hACAT-1 and hACAT-2 with IC50 values of 43.0 and 124.0μM for 1, of 39.0 and 8.0μM for 2, of 82.0μM and only 32% inhibition at 1mM for 3, respectively. The EtOAc-soluble fraction, which contained compounds 1-3, of methanol extracts of S. chinensis exhibited strong cholesterol-lowering effect in high cholesterol-fed mice.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2004.04.023

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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