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Title 

Evaluation of hesperetin 7-O-lauryl ether as lipid-lowering agent in high-cholesterol-fed rats

Authors 

G S ChoiSangku LeeTae Sook JeongM K LeeJ S LeeU J JungH J KimY B ParkSong Hae BokM S Choi

Publisher 

Elsevier

Issue Date 

2004

Citation 

Bioorganic & Medicinal Chemistry, vol. 12, no. 13, pp. 3599-3605

Keywords 

ACAThesperetin derivativeHMG-CoA reductaselipid loweringantilipemic agentcholesterolether derivativehesperetinhesperetin 7 o lauryl etherhydroxymethylglutaryl coenzyme A reductase

Abstract 

The lipid-lowering efficacy of hesperetin was revealed in preliminary studies on experimental animals. As such, the current study compared the effect of hesperetin 7-O-lauryl ether, with that of hesperetin and lovastatin on the lipid profile and cholesterol-regulating mechanism in high-cholesterol-fed rats. Male rats were fed a high-cholesterol diet (1%, wt/wt) or high-cholesterol diet supplemented with lovastatin (1, 0.02%, wt/wt), hesperetin (2, 0.02%, wt/wt), or hesperetin 7-O-lauryl ether (3, 0.031%, wt/wt) for six weeks. The supplemental amount of 3 was 0.066mmol/100g diet as an equivalent to the supplemental amount of 2. The plasma total cholesterol and triglyceride levels were significantly lowered by the 2 and 3 supplements compared with the control or 1-supplemented group. The hepatic HMG-CoA reductase activities were also significantly lower in all the supplemented groups compared with the control group, and the hepatic ACAT activity was significantly lower in the 2- and 3-supplemented groups. The supplementation of 3 resulted in a higher excretion of total neutral sterol and total fecal sterol compared with the control or 1-supplemented group. Accordingly, overall, compound 3, exhibited a more potent plasma lipid-lowering effect than compound 1 based on inhibiting cholesterol biosynthesis and esterification, while also increasing the fecal sterol excretion.

ISSN 

0968-0896

Link 

http://dx.doi.org/10.1016/j.bmc.2004.04.020

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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