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Title 

Human hepatitis B virus-X protein alters mitochondrial function and physiology in human liver cells

Authors 

Young Ik LeeJung Me HwangJee Hye ImYoon Ik LeeNam-Soon KimD G KimDae Yeul YuH B MoonS K Park

Publisher 

American Society for Biochemistry and Molecular Biology

Issue Date 

2004

Citation 

Journal of Biological Chemistry, vol. 279, no. 15, pp. 15460-15471

Keywords 

cellscomplexationfunctionsoxygenphysiologymitochondrial functionsbiochemistryhepatitis B virus X proteinreactive oxygen metabolitevirus protein

Abstract 

The hepatitis B virus-X protein (HBx) regulates fundamental aspects of mitochondrial physiology. We show that HBx down-regulates mitochondrial enzymes involved in electron transport in oxidative phosphorylation (complexes I, III, IV, and V) and sensitizes the mitochondrial membrane potential in a hepatoma cell line. HBx also increases the level of mitochondrial reactive oxygen species and lipid peroxide production. HBx does not activate apoptotic signaling, although it sensitizes hepatoma cells to apoptotic signaling, which is dependent on reactive oxygen species. Increased intrahepatic lipid peroxidation in HBx transgenic mice demonstrated that oxidative injury occurs as a direct result of HBx expression. Therefore, we conclude that mitochondrial dysfunction is a crucial pathophysiological factor in HBx-expressing hepatoma cells and provides an experimental rationale in the investigation of mitochondrial function in rapidly renewed tissues, as in hepatocellular carcinomas.

ISSN 

0021-9258

Link 

http://dx.doi.org/10.1074/jbc.M309280200

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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