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Title 

Synthesis and cytotoxic activity of 1-(1-benzoylindoline-5-sulfonyl)-4-phenylimidazolidinones

Authors 

S H JungH S LeeN S KimHwan Mook KimM S LeeD R ChoiJ A LeeY H ChungEun Yi MoonH S HwangS K SeongD K Lee

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2004

Citation 

Archives of Pharmacal Research, vol. 27, no. 5, pp. 478-484

Keywords 

1-(1-Benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolonescytotoxicitysubstituent's effect

Abstract 

The novel 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolones 2 shows highly potent and broad cytotoxicities. Their cytotoxicities against human lung carcinoma A549, human chronic myelogenous leukemia K562, and human ovarian adenocarcinoma SK-OV-3 are compatible with doxorubicin. Compound 2p (1-[(4-aminobenzoyl)indoline-5-sulfonyl])-4-phenyl-4,5-dihydroimidazolone) exhibits a cytotoxicity that is far more potent than doxorubicin and also exhibits highly effective antitumour activities against murine (3LL, Colon 26) and human xenograft (NCI-H23, SW620) tumor models.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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