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Title 

Fenofibrate prevents obesity and hypertriglyceridemia in low-density lipoprotein receptor-null mice

Authors 

S H JeongM N KimM Y HanH H LeeJ W AhnM Z KimY H SongC O ShinKi Hoan NamT W KimG T OhM C Yoon

Publisher 

Elsevier

Issue Date 

2004

Citation 

Metabolism-Clinical and Experimental, vol. 53, no. 5, pp. 607-613

Keywords 

apolipoprotein C3fenofibratelow density lipoprotein receptorperoxisome proliferator activated receptor alphahypertriglyceridemiamouseobesityapolipoproteins Cmice

Abstract 

Our previous study demonstrated that fenofibrate improves both lipid metabolism and obesity, in part through hepatic peroxisome proliferator-activated receptor α (PPARα) activation, in female ovariectomized, but not in sham-operated, low-density lipoprotein receptor-null (LDLR-null) mice. The aim of this study was to determine whether fenofibrate prevents obesity and hypertriglyceridemia in male LDLR-null mice. Mice fed a high-fat diet for 8 weeks exhibited increases in body and white adipose tissue (WAT) weights and developed severe hypertriglyceridemia compared with mice fed a low-fat control diet. However, these effects were effectively prevented by fenofibrate. Mice given a fenofibrate-supplemented high-fat diet showed significantly reduced body weight, WAT weight, and serum triglycerides versus high-fat diet-fed animals. Triton WR1339 study showed that fenofibrate-induced reduction in circulating triglycerides was due to the decreased secretion of triglycerides from the liver. Moreover, the administration of fenofibrate not only resulted in liver hypertrophy and reduction in hepatic lipid accumulation, but also regulated the transcriptional expression of PPARα target genes, such as hepatic acyl-coenzyme A (CoA) oxidase and apolipoprotein C-III (apoC-III). Therefore, our results suggest that alterations in hepatic PPARα action by fenofibrate seem to suppress diet-induced obesity and severe hypertriglyceridemia caused by LDLR deficiency in male mice.

ISSN 

0026-0495

Link 

http://dx.doi.org/10.1016/j.metabol.2003.12.010

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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