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Title 

Quinolone alkaloids with inhibitory activity against nuclear factor of activated T cells from the fruits of Evodia rutaecarpa

Authors 

H Z JinJeong-Hyung LeeDongho LeeHyun Sun LeeYoung-Soo HongY H KimJung Joon Lee

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2004

Citation 

Biological & Pharmaceutical Bulletin, vol. 27, no. 6, pp. 926-928

Keywords 

evodia rutaecarpanuclear factor activated T cellnuclear factor-κBquinolone alkaloidalkaloid derivativeevodia fruitimmunoglobulin enhancer binding proteinparthenolidequinolone derivativetranscription factor NFAT

Abstract 

Nine quinolone alkaloids (1 - 9) from the fruits of Evodia rutaecarpa were investigated for their inhibitory activity on nuclear factor of activated T cells (NFAT)-dependent transcription in comparison with nuclear factor (NF)-κB-dependent transcription using a reporter gene assay. These alkaloids showed inhibitory effects against NFAT activity, with IC50 values between 0.91 μM and 15.91 μM. of the N-methylated quinolones, the longer aliphatic side chain at the quinolone ring showed stronger inhibition of NFAT activity. These N-methylated compounds showed comparable inhibitory effects against NF-κB activity. However, quinolone alkaloids without the N-methyl group showed a more selective inhibition of NFAT activity.

ISSN 

0918-6158

Link 

http://dx.doi.org/10.1248/bpb.27.926

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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