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Title 

Acyl-CoA: cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas

Authors 

Ming-Zhe XuWoo Song LeeMi Jeong KimDoo Sang ParkHana YuG R TianTae Sook JeongHo Yong Park

Publisher 

Elsevier

Issue Date 

2004

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 14, no. 16, pp. 4277-4280

Keywords 

ACAT inhibitorsmylabris phalerate pallasthe insectacetic acid ethyl esteramidecholesterol acyltransferase inhibitorfatty acidamidesfatty acidssterol o-acyltransferase

Abstract 

Unsaturated fatty acid amides, 9(Z)-octadecenamide (2) and 9(Z),12(Z)-octadecadienamide (4) as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT) were isolated from the ethyl acetate extracts of the insect, Mylabris phalerate Pallas, and elucidated by their spectroscopic data analysis. Compounds 2 and 4 inhibited rat liver microsomal ACAT, hACAT-1, and hACAT-2 with IC50 values of 170, 85, and 63μM for 2 and of 151, 53, and 45μM for 4, respectively.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2004.05.086

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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