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Title 

Lactoferrin works as a new LPS-binding protein in inflammatory activation of macrophages

Authors 

Y J NaSang Bae HanJong Soon KangYeo Dae YoonSong Kyu ParkHwan Mook KimKyu-Hwan YangC O Joe

Publisher 

Elsevier

Issue Date 

2004

Citation 

International Immunopharmacology, vol. 4, no. 9, pp. 1187-1199

Keywords 

lactoferrinlipopolysaccharidemacrophagetoll-like receptor 4immunoglobulin enhancer binding proteinlipopolysaccharide binding proteinanimal cellcomplex formationfemaleimmunomodulation

Abstract 

Though lactoferrin (LF) is a glycoprotein that is involved in immunomodulation, its action mechanism has not been fully elucidated. Previous studies have suggested that lipopolysaccharide (LPS) activity is inhibited by direct binding between LPS and LF. However, here we show that when LPS and purified LF was mixed, and formed a complex (termed as LF-LPS), it was found to induce production of inflammatory mediators in macrophages to some extent, rather than inhibit LPS activity. Moreover, when macrophages were pretreated with LF-LPS, cells were rendered a tolerant state to LPS challenge. These macrophage-activating effects were mediated by Toll-like receptor 4 (TLR4)-NF-κB pathway. Comparative studies with C3H/HeN and C3H/HeJ mice demonstrated the strong dependency of the LF-LPS signal on TLR4. These findings suggest that the immunomodulatory properties of LF could be due, in part, to LPS binding.

ISSN 

1567-5769

Link 

http://dx.doi.org/10.1016/j.intimp.2004.05.009

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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