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Title 

Immunohistochemical expression of galectin-3 in canine mammary tumours

Authors 

Yang Kyu ChoiS H HongB H KimHyoung-Chin KimH J WooD Y Kim

Publisher 

Elsevier

Issue Date 

2004

Citation 

Journal of Comparative Pathology, vol. 131, no. 2, pp. 242-245

Keywords 

doggalectin-3mammary neoplasiatumourgalectin 3mammary glandprotein expressionmammary neoplasms, animal

Abstract 

Galectin-3, an endogenous β-galactoside-binding protein, plays a significant role in cell growth, cell activation, and cell to extracellular matrix interactions. To define the role of galectin-3 in canine mammary tumours, its expression was determined in mammary samples by immunohistochemical methods. In adjacent normal mammary glands, distant from the neoplasm, mammary epithelial cells showed little or no expression of galectin-3. In the majority of adenomas, the neoplastic cells showed moderate to strong galectin-3 immunoreactivity, but in the majority of adenocarcinomas such immunoreactivity was weak. These results suggest that the progression of canine mammary tumours is associated with low galectin-3 expression.

ISSN 

0021-9975

Link 

http://dx.doi.org/10.1016/j.jcpa.2004.02.002

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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