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Title 

Increased expression of IL-18 in cutaneous graft-versus-host disease

Authors 

H J ParkJ E KimJ Y LeeB K ChoW J LeeT KimDo Young YoonD H Cho

Publisher 

Elsevier

Issue Date 

2004

Citation 

Immunology Letters, vol. 95, no. 1, pp. 57-61

Keywords 

acute GVHDchronic GVHDIL-18interleukin 18disease coursedisease markergraft versus host reactionskin graftchronic diseasegraft vs host disease

Abstract 

Interleukin-18 (IL-18) is an 18-kDa cytokine produced by lipopolysaccharide (LPS)-activated macrophages or Kupffer cells. In addition, IL-18 is also produced by many different types of cells and tissues, including epidermal keratinocytes, the adrenal cortex, and the brain. IL-18 acts on the immune system to increase IFN-γ production from T and NK cells to enhance NK cell cytotoxicity and to activate Th1 cell proliferation. It is considered that the tissue expression of cytokines and cell adhesion molecules such as ICAM-1 are common in graft-versus-host disease (GVHD). Recent evidence suggests that IL-18 is a cytokine relevant in the pathogenesis of GVHD. Despite the potential importance of IL-18 in GVHD, the distribution of IL-18 production in cutaneous GVHD has not been fully investigated. In this study, the expression of IL-18 in the cutaneous GVHD was investigated. Formalin-fixed, paraffin-embedded tissue sections were obtained, and immunohistochemical analysis was performed to detect IL-18 and ICAM-1 expression according to the acute and chronic GVHD. Immunohistochemical analysis confirmed the enhanced IL-18 expression levels in the early stage (grade 1) of acute GVHD and the late stage (sclerodermoid) of chronic GVHD compared to the other stages. In contrast, the ICAM-1 expression level was constant at all stages. Our findings indicate that IL-18 is a significant pathogenic indicator in cutaneous GVHD, and the tissue expression of IL-18 seems to be associated with the pathogenesis of acute and chronic GVHD.

ISSN 

0165-2478

Link 

http://dx.doi.org/10.1016/j.imlet.2004.06.011

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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