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Title 

Total synthesis and absolute stereochemistry of (9R,10S)-epoxyheptadecan-4,6-diyn-3-one, a diacylglycerol acyltransferase inhibitor from Panax ginseng

Authors 

Jung-Hoon OhHyun Sun LeeMun Chual RhoYoung Kook KimHyeong Kyu LeeWoo Song LeeJ N KimSangku LeeS H Jung

Publisher 

Elsevier

Issue Date 

2004

Citation 

Tetrahedron Letters, vol. 45, no. 38, pp. 7077-7079

Keywords 

absolute configurationasymmetric synthesisepoxidationstereochemistrytotal synthesisacyltransferase inhibitordiacylglycerol acyltransferaseepoxyheptadecan 4,6 diyn 3 oneginseng extractunclassified drug

Abstract 

Asymmetric synthesis of four possible stereoisomers of (9,10)- epoxyheptadecan-4,6-diyn-3-one was accomplished, and the absolute configuration of the naturally occurring (9R,10S)-epoxyheptadecan-4,6-diyn-3-one (1) was elucidated.

ISSN 

0040-4039

Link 

http://dx.doi.org/10.1016/j.tetlet.2004.07.153

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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