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Title 

The distribution and expression of HERV families in the human genome

Authors 

T H KimYeo Jin JeonJ M YiDae Soo KimJ W HuhCheol-Goo HurH S Kim

Publisher 

Springer Verlag (Germany)

Issue Date 

2004

Citation 

Molecules and Cells, vol. 18, no. 1, pp. 87-93

Keywords 

distributionexpressionfunction categorygenome stabilityHERV elementshuman genomeidentificationhumanhuman endogenous retrovirusnonhuman

Abstract 

The families of human endogenous retroviruses (HERVs) are widely distributed in the human genome. Here we examined their distribution and expression. Approximately forty thousand HERV elements including truncated and solitary long terminal repeats (LTRs) were identified. These elements were most dense on chromosomes 4, 20, X, and Y. From an analysis of genomic stability during primate evolution, the 5′-LTR of the HERV genome (5′LTR - internal HERV - 3′LTR) appeared to be more often truncated than the 3′-LTR. ESTs derived from normal placenta, skeletal muscle, hypothalamus, and testis gave frequent matches to HERV elements. We present a classification of genes associated with HERV elements according to the hierarchical structure of gene ontology.

ISSN 

1016-8478

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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