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Title 

Guineensine, an Acyl-CoA: cholesterol acyltransferase inhibitor, from the fruits of Piper longum

Authors 

Seung Woong LeeMun Chual RhoJung Yeon NamEun Hee LimOh Eok KwonY H KimHyun Sun LeeYoung Kook Kim

Publisher 

Georg Thieme Verlag

Issue Date 

2004

Citation 

Planta Medica, vol. 70, no. 7, pp. 678-679

Keywords 

cholesterol acyltransferase inhibitorpiper longum extractpiper longumenzyme inhibitorsfruitpipersterol o-acyltransferase

Abstract 

Bioactivity-guided fractionations for ACAT inhibitor led to the isolation of guineensine from the CHCl3 extract of Piper longum. Its structure was identified by spectroscopic means (IR, UV, MS and NMR). Guineensine inhibited ACAT activity in a dose-dependent manner with an IC50 value of 3.12 μM.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2004-827193

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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