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Title 

A new VHR dual-specificity protein tyrosine phosphatase inhibitor from Dendrobium moniliforme

Authors 

Eun Young BaeHyuncheol OhWon Keun OhMin Soo KimBeom Seok KimBo Yeon KimC B SohnH OsadaJong Seog Ahn

Publisher 

Georg Thieme Verlag

Issue Date 

2004

Citation 

Planta Medica, vol. 70, no. 9, pp. 869-870

Keywords 

5 hydroxy 3,7 dimethoxy 1,4 phenanthrenequinone7 hydroxy 5,6 dimethoxy 1,4 phenanthrenequinoneanthraquinone derivativedendrobium moniliforme extractphenanthraquinoneplant extractprotein tyrosine phosphataseprotein tyrosine phosphatase inhibitorunclassified drugvaccinia open reading frame h1 related protein phosphatase

Abstract 

Bioassay-guided fractionation of the EtOAc-soluble extract of Dendrobium moniliforme afforded a new phenanthraquinone-type metabolite, 7-hydroxy-5,6-dimethoxy-1,4-phenanthrenequinone (1), along with the previously reported 5-hydroxy-3,7-dimethoxy-1,4-phenanthrenequinone (2). The structures of the compounds were identified mainly on the basis of MS and NMR data. Compound 1 inhibited VHR dual-specificity protein tyrosine phosphatase (DS-PTPase) activity in a dose-dependent manner, displaying an IC50 value of 3.0 ± 0.2 μM.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2004-827238

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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