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Title 

Natural inhibitors of carcinogenesis

Authors 

A D KinghornB N SuD S JangL C ChangDongho LeeJ Q GuE J Carcache-BlancoA D PawlusS K LeeE J ParkM CuendetJ J GillsK BhatH S ParkE Mata-GreenwoodL L SongM JangJ M Pezzuto

Publisher 

Georg Thieme Verlag

Issue Date 

2004

Citation 

Planta Medica, vol. 70, no. 8, pp. 691-705

Keywords 

edible plantsflavonoidsin vitro bioassaysmouse mammary organ cultureplant secondary metabolitespotential cancer chemopreventive agentsstilbenoidsstructure-activity relationshipswithanolidescarcinogenesis

Abstract 

Previous collaborative work by our group has led to the discovery of several plant isolates and derivatives with activities in in vivo models of cancer chemoprevention, including deguelin, resveratrol, bruceantin, brassinin, 4′-bromoflavone, and oxomate. Using a panel of in vitro bioassays to monitor chromatographic fractionation, a diverse group of plant secondary metabolites has been identified as potential cancer chemopreventive agents from mainly edible plants. Nearly 50 new compounds have been isolated as bioactive principles in one or more in vitro bioassays in work performed over the last five years. Included among these new active compounds are alkaloids, flavonoids, stilbenoids, and withanolides, as well as a novel stilbenolignan and the first representatives of the norwithanolides, which have a 27-carbon atom skeleton. In addition, over 100 active compounds of previously known structure have been obtained. Based on this large pool of potential cancer chemopreventive compounds, structure-activity relationships are discussed in terms of the quinone reductase induction ability of flavonoids and withanolides and the cyclooxygenase-1 and -2 inhibitory activities of flavanones, flavones and stilbenoids. Several of the bioactive compounds were found to be active when evaluated in a mouse mammary organ culture assay, when used as a secondary discriminator in our work. The compounds (2S)-abyssinone II, (2S)-2′,4′-dihydroxy-2″-(1-hydroxy-1-methylethyl) dihydrofuro[2,3-h]-flavanone, 3′-[γ-hydroxymethyl-(E)-γ- methylallyl]-2,4,2′,4′-tetrahydroxychalcone 11′-O-coumarate, isolicoflavonol, isoliquiritigenin, and ixocarpalactone A are regarded as promising leads as potential cancer chemopreventive agents.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2004-827198

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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