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Title 

Differential DNA methylation reprogramming of various repetitive sequences in mouse preimplantation embryos

Authors 

Seok Ho KimYong-Kook KangDeog Bon KooM J KangS J MoonKyung Kwang LeeYong Mahn Han

Publisher 

Elsevier

Issue Date 

2004

Citation 

Biochemical and Biophysical Research Communications, vol. 324, no. 1, pp. 58-63

Keywords 

DNA methylationepigenetic reprogrammingmousepreimplantation embryorepetitive sequencesDNAdemethylationDNA sequenceembryo

Abstract 

Genome-wide changes of DNA methylation by active and passive demethylation processes are typical features during preimplantation development. Here we provide an insight that epigenetic reprogramming of DNA methylation is regulated in a region-specific manner, not a genome-wide fashion. To address this hypothesis, methylation states of three repetitive genomic regions were monitored at various developmental stages in the mouse embryos. Active demethylation was not observed in the IAP sequences whereas methylation reprogramming of the satellite sequences was regulated only by the active mechanism. Etn elements were actively demethylated after fertilization, passively demethylated by the 8-cell stage, and de novo methylated at the morular and blastocyst stages, showing dynamic epigenetic changes. Thus, our findings suggest that the specific genomic regions or sequences may spatially/temporally have their unique characteristics in the reprogramming of the DNA methylation during preimplantation development.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2004.09.023

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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