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Title 

Synthesis and cytotoxicity of 2,5-dihydroxychalcones and related compounds

Authors 

N H NamD H HongY J YouY KimS C BangHwan Mook KimB Z Ahn

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2004

Citation 

Archives of Pharmacal Research, vol. 27, no. 6, pp. 581-588

Keywords 

chalconecytotoxicitystructure-activity relationship2',5' dihydroxychalcone2',5'-dihydroxychalconesynthesis

Abstract 

A series of 2, 5-dihydroxychalcones and related compounds were synthesized, and their cytotoxicities against tumor cell lines and human umbilical venous endothelial cells (HUVEC) evaluated. It was found that chalcones, with electron-withdrawing substituents on an A ring, exhibited significant cytotoxicities. Among the synthesized compounds, 2′-chloro-2, 5-dihydroxychalcone (9) was most potent, with an IC50 value as low as 0.31 μg/mL. This compound also exhibited a significant cytotoxic selectivity toward HUVEC.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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