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Title 

Water-soluble polysaccharide from Eleutherococcus senticosus stems attenuates fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice

Authors 

E J ParkJ X NanY Z ZhaoS H LeeY H KimJeong Bum NamJung Joon LeeD H Sohn

Publisher 

Wiley

Issue Date 

2004

Citation 

Basic & Clinical Pharmacology & Toxicology, vol. 94, no. 6, pp. 298-304

Keywords 

eleutherococcus senticosus extractgalactosaminelipopolysaccharidepolysaccharidealanine aminotransferase blood levelanimal modelaspartate aminotransferase blood levelcontrolled studydrug isolationeleutherococcus senticosus

Abstract 

The aim of this study was to investigate whether Eleutherococcus senticosus stems could attenuate D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure in mice. E. senticosus, known as Siberian ginseng, is a popular folk medicine used as a tonic in Asia. Preparations of E. senticosus used in this study were as follows; (i) 70% ethanol extract (ii) water extract (iii) ethanol-soluble part of the water extract (iv) polysaccharide obtained as an 80% ethanol insoluble of the water extract. Preparations were given by intraperitoneal (300 mg/kg and 50 mg/kg) or oral (300 mg/kg) injection at 12 hr and 1 hr before a D-galactosamine/lipopolysaccharide injection. The intraperitoneal injection of water extract and polysaccharide significantly lowered serum levels of tumour necrosis factor-α, aspartate transaminase and alanine transaminase, improved the histologic changes in liver, inhibited hepatocyte apoptosis confirmed by the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling method and DNA fragmentation assay, and suppressed the lethality induced by D-galactosamine/lipopolysaccharide. The oral administration of water extract and polysaccharide also reduced serum aspartate transaminase, alanine transaminase and tumour necrosis factor-α levels. In contrast 70% ethanol extract and ethanol-soluble part of the water extract had no protective effect when treated intraperitoneally or orally. These results indicate E. senticosus stems attenuate fulminant hepatic failure induced by D-galactosamine/lipopolysaccharide in mice and the protective effect is due to water-soluble polysaccharides in E. senticosus stems.

ISSN 

1742-7835

Link 

http://dx.doi.org/10.1111/j.1742-7843.2004.pto940607.x

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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