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Title 

Increase of caspase-3 activity by lignans from Machilus thunbergii in HL-60 cells

Authors 

Bo Young ParkByung Sun MinOk Kyoung KwonSei Ryang OhKyung Seop AhnT J KimDoo-Young KimK H BaeHyeong Kyu Lee

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2004

Citation 

Biological & Pharmaceutical Bulletin, vol. 27, no. 8, pp. 1305-1307

Keywords 

apoptosiscaspase-3dna fragmentationlignanmachilus thunbergiicaspase 3machilus thunbergii extractCASP3 protein, humancaspasecell strain HL 60

Abstract 

Nine lignans and two butanolides were isolated from the stem bark of Machilus thunbergii and their structures were identified as machilin A (1), licarin B (2), zuonin B (3), macelignan (4), secoisolancifolide (5), isolancifolide (6), oleiferin C (7), meso-dihydroguaiaretic acid (8), licarin A (9), machilin F (10), and nectandrin B (11) by spectroscopic means. These compounds were assessed for their abilities to activate a caspase-3 activity in human promyeloid leukemic HL-60 cells. The intracellular caspase-3 activity of macelignan (4), oleiferin C (7), meso-di-hydroguaiaretic acid (8), and licarin A (9) increased approximately 3.04, 6.16, 2.10, and 3.10-fold at 100 μM over that of untreated control. In addition, compounds 4, 7, 8, and 9 induced internucleosomal DNA fragmentation in HL-60 cells.

ISSN 

0918-6158

Link 

http://dx.doi.org/10.1248/bpb.27.1305

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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