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Title 

Comparative study of cholinergic cells in retinas of various mouse strains

Authors 

T H KangYoung Han RyuI B KimGoo Taeg OhM H Chun

Publisher 

Springer Verlag (Germany)

Issue Date 

2004

Citation 

Cell and Tissue Research, vol. 317, no. 2, pp. 109-115

Keywords 

amacrine cellcholine acetyltransferasehorizontal cellmouse (BALB/C albino, C57BL/6J black, and 129/SvJ light chinchilla)retinacholinergic nerve cellcontrolled studyimmunocompetent cellmousemouse strain

Abstract 

We examined cholinergic cells in the retinas of BALB/C albino, C57BL/6J black, and 129/SvJ light chinchilla mice by using immunocytochemistry with specific antisera against choline acetyltransferase (ChAT). Two types of ChAT-immunoreactive amacrine cell bodies were found in the inner nuclear layer (INL) and ganglion cell layer in the retinas of all three mouse strains. They were distributed with mirror-image symmetry and their processes ramified in strata 2 and 4 of the inner plexiform layer. A distinct type of ChAT-immunoreactive cell was found only in C57BL/6J mouse retina. The somata of this third type of ChAT-immunoreactive cell were located in the outermost part of the INL, with their processes extending toward the outer plexiform layer. Double-labeling experiments demonstrated that these were not horizontal cells and that they were GABA-immunoreactive. The results suggested that these cells were probably "misplaced" cholinergic amacrine cells showing GABA immunoreactivity. This feature of the C57BL/6J mouse retina should be taken into account in studies of mutant mice having a mixed genetic background with a C57BL/6J contribution.

ISSN 

0302-766X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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