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Title 

The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens

Authors 

S H HongJ S KimS Y LeeY H InS S ChoiJeong Keun RhiChang Hoon KimHaeyoung JeongCheol-Goo HurJ J Kim

Publisher 

Nature Publishing Group

Issue Date 

2004

Citation 

Nature Biotechnology, vol. 22, no. 10, pp. 1275-1281

Keywords 

bacteriagenome sequencerumenbacterial genomebacterial metabolismgene sequencemannheimiamannheimia succiniciproducensnucleotide sequencerumination

Abstract 

The rumen represents the first section of a ruminant animal's stomach, where feed is collected and mixed with microorganisms for initial digestion. The major gas produced in the rumen is CO2 (65.5 mol%), yet the metabolic characteristics of capnophilic (CO2-loving) microorganisms are not well understood. Here we report the 2,314,078 base pair genome sequence of Mannheimia succiniciproducens MBEL55E, a recently isolated capnophilic Gram-negative bacterium from bovine rumen, and analyze its genome contents and metabolic characteristics. The metabolism of M. succiniciproducens was found to be well adapted to the oxygen-free rumen by using fumarate as a major electron acceptor. Genome-scale metabolic flux analysis indicated that CO2 is important for the carboxylation of phosphoenolpyruvate to oxaloacetate, which is converted to succinic acid by the reductive tricarboxylic acid cycle and menaquinone systems. This characteristic metabolism allows highly efficient production of succinic acid, an important four-carbon industrial chemical.

ISSN 

1087-0156

Link 

http://dx.doi.org/10.1038/nbt1010

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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