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Title 

Inhibition of PTP1B by metabolites from Micromucor ramannianus var. amgulisporus CRM000232

Authors 

Hyuncheol OhBeom Seok KimEun Young BaeMin Soo KimBo Yeon KimH B LeeChang-Jin KimJong Seog Ahn

Publisher 

Nature Publishing Group

Issue Date 

2004

Citation 

Journal of Antibiotics, vol. 57, no. 8, pp. 528-531

Keywords 

enzyme inhibitionmicromucor ramannianus

Abstract 

In summary, dimeric depside-type fungal matabolite 1, along with biogenetically related compounds 2 and 3, was isolated as a PTP1B inhibitor by bioassay guided fractionation from the EtOAc extract of M. ramannianus var. angulisporus. To our best knowledge, compound 1 is the first PTP1B inhibitor reported from fungal sources, and it could serve as a lead compound in design and development of potent PTP-1B inhibitor.

ISSN 

0021-8820

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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