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Title 

Somatostatin controls LFA-1 gene expression by altering neuraminidase expression in spleen cells

Authors 

Woon Kee YoonH J KimH Y SonK S JeongS J ParkT H KimS H KimS R KimS Y Ryu

Publisher 

International Institute of Anticancer Research (IIAR)

Issue Date 

2004

Citation 

Anticancer Research, vol. 24, no. 4, pp. 2331-2336

Keywords 

LFA-1neuraminidasesomatostatinsubstance Plymphocyte function associated antigen 1Neu 1 sialidaseanimal cellcell culturegene expression regulation

Abstract 

This study investigated whether neuraminidase (Neu) affects LFA-1 mRNA expression in spleen cells and whether somatostatin (SOM) and substance P (SP) treatment induce changes in the Neu mRNA expression level in spleen cells. Neu treatments down-regulated the LFA-1 mRNA levels after culturing for 2 h. SOM increased the Neu mRNA level slightly after 24-h culture and strongly after 48-h culture. These results suggest that prolonged exposure to SOM may regulate the Neu activation pathway, which in turn impairs the regulation of LFA-1 expression.

ISSN 

0250-7005

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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