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Title 

Screening of anti-atherogenic substances from insect resources

 

곤충자원으로부터 항동맥경화 활성물질 탐색

Authors 

Doo Sang ParkMi Ae YoonMingZhe SuHa Na YuJu Ryoung KimTae Sook JeongHo Yong Park

Publisher 

Korean Society of Pharmacognosy

Issue Date 

2004

Citation 

Korean Journal of Pharmacognosy, vol. 35, no. 3, pp. 233-238

Keywords 

ACATatherosclerosisinhibitorinsect resourcesLDL-oxidationLp-PLA2antiatherogenic substancedrug screeninginsectinsect extract

Abstract 

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a potential biomarker of coronary heart disease and plays an important proinflammatory role in the progression of atherosclerosis. Also acyl-CoA: cholesterol acyltransferase (ACAT) and oxidized low-density lipoprotein (LDL) play a key role in atherosclerosis, respectively. And so, the inhibitory activities of the methanol extracts of 42 insect resources were examined on Lp-PLA2, ACAT, and LDL oxidation for screening of anti-atherogenic substances. Among them, the methanol extracts of Eurydema rugosa significantly inhibited all of upper three activities. Several kinds of tested insects having high inhibitory effect with the methanol extracts were extracted with n-hexane, ethyl acetate, and acetone, and their inhibitory activities were tested.

ISSN 

0253-3073

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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