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Title 

Antioxidant activities of a new lignan and a neolignan from Saururus chinensis

Authors 

Woo Song LeeYoung Il BaekJu Ryoung KimKyung Hyun ChoD E SokTae Sook Jeong

Publisher 

Elsevier

Issue Date 

2004

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 14, no. 22, pp. 5623-5628

Keywords 

LDL-antioxidant2' hydroxydihydroguaiaretic acidalkadieneherbaceous agentlignanneolignansaururus chinensis extractthiobarbituric acidunclassified drugantioxidant activity

Abstract 

new diarylbutane lignan, 2′-hydroxy dihydroguaiaretic acid (4), and a known 8-O-4′-type neolignan, machilin D (5) were isolated from the ethyl acetate extracts of Saururus chinensis root and exhibited low-density lipoprotein (LDL)-antioxidant activity and radical DPPH scavenging activity. A new diarylbutane lignan, 2′-hydroxy dihydroguaiaretic acid (4), and a known 8-O-4′-type neolignan, machilin D (5), were isolated from the ethyl acetate extracts of the underground parts of Saururus chinensis. Compounds 4 and 5 exhibited low-density lipoprotein (LDL)-antioxidant activity in the thiobarbituric acid-reactive substances (TBARS) assay (4: IC50 = 3.3 μM and 5: IC50 = 3.8 μM), the lag time of conjugated diene production, the relative electrophoretic mobility (REM) of ox-LDL, the apoB-100 fragmentation on copper-mediated LDL oxidation and the macrophage-mediated LDL oxidation, and radical DPPH scavenging activity.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2004.08.054

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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