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Title 

Phenylpropanoids from Myristica fragrans houtt

 

육두구(Myristica fragrans Houtt)로부터 phenylpropanoid의 분리

Authors 

M C SongE M AhnM H BangS Y KimY D RhoByoung-Mog KwonHyun Sun LeeN I Baek

Publisher 

Korean Society for Applied Biological Chemisty

Issue Date 

2004

Citation 

Journal of Korean Society for Applied Biological Chemistry, vol. 47, no. 3, pp. 366-369

Keywords 

myristica fragrans Houttmeso-dihydroguaiaretic acidnectandrin Bsyringin metyl etherchitin synthase Ⅲ

Abstract 

Myristica fragrans Houtt were extracted in 80% aq. MeOH and solvent fractionated using CHCl3, EtOAc, n-BuOH and water, successively. The n-BuOH fraction gave three phenylpropanoids through application of silica gel column chromatographies. The chemical structures of the phenylpropanoids were determined by the interpretation of several spectral data, including NMR and MS as meso-dihydroguaiaretic acid (1), nectandrin B (2) and syringin methyl ether (3). Compound 1, which was first isolated from this plant by authors, showed inhibitory activities with 60.0?2.1% (100 μg/ml), 42.6?0.9% (140 μg/ml) and 12.2?0.2% (200 μg/ml) on ACAT(acyl-CoA:Cholesterol Acyltransferase), chitin synthase III and HMG-CoA reductase (3-hydroxy-3-methylglutaryl coenzyme A reductase), respectively. Compound 3 showed inhibitory activities with 27.2?0.9% (100 μg/ml), 45.5?0.8% (200 μg/ml) on ACAT and chitin synthase III.

ISSN 

1738-2203

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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