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Title 

식용 식물자원으로부터 활성물질의 탐색-X.: 능소화(Campsis grandiflora K. schum.)로부터 지질화합물의 분리 및 FPTase 저해 효과 측정

Authors 

D H KimM C SongK M HanM H BangByoung-Mog KwonS H KimD K KimI S ChungM H ParkN I Baek

Publisher 

Korean Society for Applied Biological Chemisty

Issue Date 

2004

Citation 

Journal of Korean Society for Applied Biological Chemistry, vol. 47, no. 3, pp. 357-360

Keywords 

campsis grandiflora K. Schum.linoleic acidlinolenic acidβ-sitosteroldaucosterolFPTase

Abstract 

The flower of Campsis grandiflora K. Schum. was extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and H2O. From the EtOAc fraction, four compounds were isolated through the repeated silica gel and ODS column chromatographies. From the result of physico-chemical data including NMR, MS and IR, the chemical structures of the compounds were determined as linolenic acid methyl ester, linoleic acid methyl ester, β-sitosterol and daucosterol. Daucosterol inhibited FPTase activity with IC50 values of 14±0.04 μM.

ISSN 

1738-2203

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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