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Title 

Inhibitors of the LPS-induced NF-κB activation from Artemisia sylvatica

Authors 

H Z JinJeong-Hyung LeeDongho LeeYoung-Soo HongY H KimJung Joon Lee

Publisher 

Elsevier

Issue Date 

2004

Citation 

Phytochemistry, vol. 65, no. 15, pp. 2247-2253

Keywords 

artemisia sylvaticacompositaeCOX-2iNOSNF-κBNOsesquiterpene lactoneTNF-α

Abstract 

Three guaianolide type sesquiterpene lactones, 3α,4α- epoxyrupicolins C-E (1-3), together with six known sesquiterpenes (4-9) were isolated and identified from the methanol extract of the aerial parts of Artemisia sylvatica, and their biological activities were reported. Three guaianolide sesquiterpene lactones, 3α,4α-epoxyrupicolins C-E, together with six known sesquiterpenes, artemisolide, 3-methoxytanapartholide, deacetyllaurenobiolide, moxartenolide as well as arteminolides B and D were isolated by bioassay-guided fractionation from the methanol extract of the aerial parts of Artemisia sylvatica using the NF-κB mediated reporter gene assay. All isolated compounds displayed inhibitory activity on the LPS-induced NF-κB activation, NO production, and TNF-α production with IC 50 values of 0.49-7.17, 1.46-6.16, and 3.19-27.76 μM, respectively, in RAW264.7 cells. It was also established that arteminolide B suppressed the expression of NF-κB target genes such as iNOS and COX-2. This is the first report of NF-κB inhibitory activities of these compounds and supports the pharmacological use of Artemisia sylvatica, which has been employed as an herbal medicine for the treatment of inflammation.

ISSN 

0031-9422

Link 

http://dx.doi.org/10.1016/j.phytochem.2004.06.034

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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