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Title 

Enhancement of tyrosinase inhibition of the extract of Veratrum patulum using cellulase

Authors 

Dong Hyun KimJin Hee KimSeung Hwa BaekJ H SeoYung Hee KhoTae Kwang OhChoong Hwan Lee

Publisher 

Wiley-Blackwell

Issue Date 

2004

Citation 

Biotechnology and Bioengineering, vol. 87, no. 7, pp. 849-854

Keywords 

biotransformationcellulaseresveratroltyrosinase inhibitorveratrum patulumenzyme inhibitionextractionplant extractsacer barbinerve extractbroussonetia kazinoki extract

Abstract 

Inhibitors of melanin biosynthesis were screened by using three different methods. The extract of Veratrum patulum contains hydroxystilbene compounds that are potent tyrosinase inhibitors. We evaluated the enzyme inhibitory property on the mushroom tyrosinase of hydroxystilbene compounds including resveratrol, oxyresveratrol, and their analogs. Biotransformation using cellulase of the whole extract brought about an increase in the inhibitory activity of the products on mushroom tyrosinase. The enhancement of tyrosinase inhibition is supposed to increase the concentration of aglycon, which has superior inhibitory activity to its glycoside. Eventually, melanin biosynthesis was inhibited by the enhanced tyrosinase inhibitory activity of the extract. This result indicated that deglycosylation of stilbene compounds has exerted more effective inhibition on the enzyme than that of the unprocessed plant extract.

ISSN 

0006-3592

Link 

http://dx.doi.org/10.1002/bit.20189

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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