상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Ameliorating effect of the root extract from Platycodon grandiflorum on the ethanol-induced cognitive impairment in mice

 

에탄올 투여로 유도한 생쥐의 인지기능 손상에 대한 길경 추출물의 개선효능

Authors 

Y S KimJ S KimY H ChoiJ H SeoJ W LeeS K KimJ S KangHyun Sun LeeY S ChoS H RohY C JeongK H ShimS Y Ryu

Publisher 

Korean Society of Pharmacognosy

Issue Date 

2004

Citation 

Korean Journal of Pharmacognosy, vol. 35, no. 3, pp. 239-243

Keywords 

cognitive dysfunctionmemorypassive avoidance performanceplatycodon grandiflorumstep-through testmethanolplant extractplatycodon grandiflorum extractcognitive defectdrug effect

Abstract 

The ameliorating effect of the MeOH extract of the root of Platycodon grandiflorum on the ethanol-induced cognitive dysfunction in mice was investigated. The total MeOH extract was devided into two fractions, saponin rich fraction and non-saponin fraction. The mice with repeated administration of the total MeOH extract and those with saponin rich fraction both showed a markedly prolonged latency time upon the step-through test (passive avoidance performance) performed after acute ethanol intoxication, while those with non-saponin rich fraction did not. The results suggest that the extracts from the root of Platycodon grandiflorum exert a beneficial effect on ethanol-induced memory impairment in mice and also suggest that these effects of the extracts might be ascribed to the saponin constituents.

ISSN 

0253-3073

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)