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Title 

Enhancement of cell survival by stromal cell-derived factor-1/CXCL12 involves activation of CREB and induction of Mcl-1 and c-Fos in factor-dependent human cell line MO7e

Authors 

E K JooH E BroxmeyerH J KwonH B KangJ S KimJong-Seok LimYong Kyung ChoeIn Seong ChoeP K MyungY H Lee

Publisher 

Mary Ann Liebert

Issue Date 

2004

Citation 

Stem Cells and Development, vol. 13, no. 5, pp. 563-570

Keywords 

cyclic AMP responsive element binding proteinmitogen activated protein kinase 1protein c fosprotein mcl 1stromal cell derived factor 1cell survivalcontrolled studyhumanhuman cellprotein induction

Abstract 

Stromal cell-derived factor-1 (SDF-1/CXCL12) enhances the survival of hematopoietic stem and progenitor cells in synergy with other cytokines such as granulocyte-macrophage colony-stimulating factor (GM-CSF), steel factor, and thrombopoietin (TPO), and both the PI3K/Akt and MAPK pathways have been linked to this survival. To further evaluate intracellular signaling involved in SDF-1/CXCL12 survival effects, we investigated modulation of downstream signaling molecules. The synergistic survival enhancement of SDF-1/CXCL12 plus other cytokines were directly linked to enhanced phosphorylation of p70/85S6K and cAMP responsive element binding protein (CREB), as well as enhanced induction of the Bcl-2 family member Mcl-1. Most prominently, c-Fos, a component of AP1 transcription factor, was synergistically induced by SDF-1/CXCL12 plus other cytokines. These results suggest that SDF-1/CXCL12 enhanced cell survival in synergy with other cytokines involves activation of CREB and induction of Mcl-1 and c-Fos.

ISSN 

1547-3287

Link 

http://dx.doi.org/10.1089/scd.2004.13.563

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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