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Title 

Proteome analysis of red deer antlers

Authors 

Hee Jin ParkDo Hee LeeSung Goo ParkSang Chul LeeS Y ChoH K KimJ J KimH S BaeByoung Chul Park

Publisher 

Wiley-Blackwell

Issue Date 

2004

Citation 

Proteomics, vol. 4, no. 11, pp. 3642-3653

Keywords 

antlersgrowing tipproteomeproximal bony tissuetwo-dimensional gel electrophoresisaldehyde reductaseprotein analysisred deer

Abstract 

Deer antlers are the only mammalian organs capable of repeated regeneration. Although antlers are known to develop from pedicles, which arise from antlerogenic cells of cranial periosteum, their developmental process is not fully elucidated. For example, while endocrine and environmental factors influence the antler development, it is still unclear which signaling pathways are involved in the transduction of such stimuli. To study the developmental process of antlers and identify proteins functioning in their growth, we have established proteome maps of red deer (Cervus elaphus) antlers. With two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization mass spectrometry, we analyzed more than 800 protein spots and identified ∼130 individual proteins derived from the growing tip of antlers. The overall profile of the antler proteome was dissimilar to those of other types of tissue. Also comparison of proteomes derived from proximal bony tissue and the growing tip of antlers revealed substantial differences. Moreover several cell growth or signaling-related proteins are expressed exclusively in the growing tip, suggesting that these proteins function in the growth and differentiation of antlers. Currently, using the antler proteome maps, we are actively searching for the regulatory factor(s) that may control the antler development.

ISSN 

1615-9853

Link 

http://dx.doi.org/10.1002/pmic.200401027

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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