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Title 

Identification of B-cell translocation gene 1 as a biomarker for monitoring the remission of acute myeloid leukemia

Authors 

J W ChoJeong Jung KimSung Goo ParkDo Hee LeeSang Chul LeeH J KimByoung Chul ParkS Y Cho

Publisher 

Wiley-Blackwell

Issue Date 

2004

Citation 

Proteomics, vol. 4, no. 11, pp. 3456-3463

Keywords 

acute myeloid leukemiaall-trans-retionic acidB-cell translocation genedifferentiationbiological markercarrier proteinprotein BTG1retinoic acidunclassified drugacute granulocytic leukemia

Abstract 

Acute myeloid leukemia (AML) is a biologically heterogeneous disease of the hematopoietic system characterized by a clonal accumulation of immature blast cells in bone marrow. We used a proteomic approach based on two-dimensional electrophoresis and mass spectrometry to search for biomarkers related to the complete remission (CR) state of AML patients. We detected one AML-related protein, which was identified as the B-cell translocation gene 1 (BTG1) protein that belongs to anti-proliferative protein family. In the CR state of AML-M2 and M3 patients (by French-American-British subtype classification), the BTG1 protein was upregulated in bone marrow mononuclear cells. It was also expressed robustly in normal bone marrow mononuclear cells. In addition, the BTG1 levels in AML-M2 patients in a non-remission state after therapy did not increase as they did before therapy. Overexpression of BTG1 mRNA was also observed in the CR state of all-trans-retinoic acid (ATRA)-treated AML-M3 patients and ATRA-treated HL-60 cells. Taken together, these results suggest that BTG1 may play a role in the differentiation process of myeloid cells and can therefore be used as a potential treatment-related biomarkerfor monitoring the remission status of AML-M2 and M3 patients.

ISSN 

1615-9853

Link 

http://dx.doi.org/10.1002/pmic.200400968

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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