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Title 

Identification of target proteins of N-acetylglucosaminyl-transferase V and fucosyltransferase 8 in human gastric tissues by glycomic approach

Authors 

Yong Sam KimSoo Young HwangS J OhHosung SohnHye Yeon KangJ H LeeEun Wie ChoJ Y KimJ S YooNam-Soon KimC H KimE MiyoshiN TaniguchiJeong Heon Ko

Publisher 

Wiley-Blackwell

Issue Date 

2004

Citation 

Proteomics, vol. 4, no. 11, pp. 3353-3358

Keywords 

fucosyltransferasesglycosylationhumansN-acetylglucosaminyltransferasesstomachsubstrate specificity

Abstract 

To understand better the mechanism underlying gastric cancer and search for potential markers for gastric cancer prognosis, the proteomic analysis of gastric cancer tissues was conducted using two-dimensional gel electrophoresis and lectin blot, followed by electrospray ionization-mass spectrometry. These approaches permitted identification of glyco- or putative glycosylated proteins which may be associated with tumorigenesis. The proteins identified include molecules involved in sugar metabolism, signal transduction, proteolysis, and stress, as well as several unknown proteins, which were aberrantly glycosylated as evidenced by the L-phytohemagglutinin blot.

ISSN 

1615-9853

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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