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Title 

Effect of the hesperetin and naringenin on pp60v-src -induced NF-κB activation

 

pp60v-src에 의한 NF-κB 활성화에 대한 헤스페리틴과 나린제닌의 저해 효과

Authors 

O Song KwonBo Yeon KimKyoung A KimMin Soo KimHyuncheol OhBeom Seok KimY H KimJong Seog Ahn

Publisher 

Korean Society of Pharmacognosy

Issue Date 

2004

Citation 

Korean Journal of Pharmacognosy, vol. 35, no. 3, pp. 244-249

Keywords 

AktflavonoidGSK-3hesperetinIκBαnaringeninNF-κBv-SrcI kappa B alpha

Abstract 

The effects of hesperetin and naringenin on NF-κB activation were investigated in normal rat kidney cells transformed by temperature sensitive Rous Sarcoma Virus (tsNRK). The flavonoids, naringenin and hesperetin, significantly reduced v-Src-induced NF-κB activation as well as phosphorylation of Akt and GSK-3 in tsNRK cells, whereas these compounds did not effect on platelet-derived growth factor (PDGF)-induced NF-κB activation in NIH3T3γ1 cells. In addition, the DNA binding activity of SP-1 was also reduced but that of AP-1 was not affected by the compounds. Our study suggests that Src-induced NF-κB activation could occur via Akt-GSK-3 pathway without IκBα degradation and that naringenin and hesperetin could be used in the treatment of cancer through the inhibition of NF-κB activation.

ISSN 

0253-3073

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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