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Title 

Effects of fenofibrate on high-fat diet-induced body weight gain and adiposity in female C57BL/6J mice

Authors 

S JeongM HanH LeeM KimJ KimC J NicolB H KimJ H ChoiKi Hoan NamG T OhM Yoon

Publisher 

Elsevier

Issue Date 

2004

Citation 

Metabolism-Clinical and Experimental, vol. 53, no. 10, pp. 1284-1289

Keywords 

fatty acidfenofibratefemalelipid dietweight gainbody compositionbody weightdietary fatsfatty acids

Abstract 

Our previous study suggested that fenofibrate affects obesity and lipid metabolism in a sexually dimorphic manner in part through the differential activation of hepatic peroxisome proliferator-activated receptor α (PPARα) in male and female C57BL/6J mice. To determine whether fenofibrate reduces body weight gain and adiposity in female sham-operated (Sham) and ovariectomized (OVX) C57BL/6J mice, the effects of fenofibrate on not only body weight, white adipose tissue (WAT) mass, and food intake, but also the expression of both leptin and PPARα target genes were measured. Compared to their respective low-fat diet-fed controls, both Sham and OVX mice exhibited increases in body weight and WAT mass when fed a high-fat diet. Fenofibrate treatment decreased body weight gain and WAT mass in OVX, but not in Sham mice. Furthermore, fenofibrate increased the mRNA levels of PPARα target genes encoding peroxisomal enzymes involved in fatty acid β-oxidation, and reduced apolipoprotein C-III (apo C-III) mRNA, all of which were expressed at higher levels in OVX compared to Sham mice. However, leptin mRNA levels were found to positively correlate with WAT mass, and food intake was not changed in either OVX or Sham mice following fenofibrate treatment. These results suggest that fenofibrate differentially regulates body weight and adiposity due in part to differences in PPARα activation, but not to differences in leptin production, between female OVX and Sham mice.

ISSN 

0026-0495

Link 

http://dx.doi.org/10.1016/j.metabol.2004.05.003

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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