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Title 

Tetramethoxy hydroxyflavone p7F downregulates inflammatory mediators via the inhibition of nuclear factor κB

Authors 

Hee Gu LeeHyoson KimWon Keun OhKyung Ae YuYong Kyung ChoeJong Seog AhnD S KimS H KimC A DinarelloK KimDo Young Yoon

Publisher 

Wiley-Blackwell

Issue Date 

2004

Citation 

Annals of the New York Academy of Sciences, vol. 1030, no. 0, pp. 554-567

Keywords 

flavonoidinflammationnitric oxidenuclear factor-κBreactive oxygen species5,6,3',5' tetramethoxy 7,4' hydroxyflavoneartemisia absinthium extractimmunoglobulin enhancer binding proteininducible nitric oxide synthasereactive oxygen metabolite

Abstract 

Artemisia has been traditionally used in Korean herbal medicine to clear damp heat and to treat uteritis and jaundice. Flavonoids isolated from Artemisia are also known to possess anti-inflammatory activities. In this study, 5,6,3′,5′-tetramethoxy 7,4′-hydroxyflavone (p7F) was isolated from Artemisia absinthium. We examined in vitro and in vivo regulatory functions of p7F on the production of nitric oxide (NO), prostaglandin E2 (PGE2), and tumor necrosis factor-α (TNF-α) as well as the expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), and collagen-induced arthritis. p7F inhibited the expression or production of proinflammatory mediators such as COX-2/PGE2 and iNOS/NO in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. p7F also suppressed the serum level of TNF-α in mice treated with collagen and inhibited nuclear factor-κB (NF-κB) activation as well as NF-κB promoter activity in RAW 264.7 cells stimulated with LPS. This compound directly inhibited the intracellular accumulation of reactive oxygen species in hydrogen peroxide-stimulated RAW 264.7 cells. p7F has antioxidant activity and inhibits NF-κB activation. Taken together, these results suggest that p7F can be clinically applied to the treatment of inflammatory diseases.

ISSN 

0077-8923

Link 

http://dx.doi.org/10.1196/annals.1329.065

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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