상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Hepatoprotective and free radical scavenging activities of phenolic petrosins and flavonoids isolated from Equisetum arvense

Authors 

Hyuncheol OhD H KimJ H ChoY C Kim

Publisher 

Elsevier

Issue Date 

2004

Citation 

Journal of Ethnopharmacology, vol. 95, no. 2, pp. 421-424

Keywords 

antioxidantsequisetum arvenseflavonoidshepatoprotectivephenolic petrosinsflavonoidfree radicaldrug activityequisetumfree radical scavengers

Abstract 

Hepatoprotective activity-guided fractionation of the MeOH extract of Equisetum arvense L. (Equisetaceae) resulted in the isolation of two phenolic petrosins, onitin (1) and onitin-9-O-glucoside (2), along with four flavonoids, apigenin (3), luteolin (4), kaempferol-3-O-glucoside (5), and quercetin-3-O-glucoside (6). Among these, compounds 1 and 4 exhibited hepatoprotective activities on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells, displaying EC50 values of 85.8 ± 9.3 μM and 20.2 ± 1.4 μM, respectively. Silybin, used as a positive control, showed the EC50 value of 69.0 ± 3.3 μM. Compounds 1 and 4 also showed superoxide scavenging effects (IC50 = 35.3 ± 0.2 μM and 5.9 ± 0.3 μM, respectively) and DPPH free radical scavenging effect (IC50 of 35.8 ± 0.4 μM and 22.7 ± 2.8 μM, respectively). These results support the use of this plant for the treatment of hepatitis in oriental traditional medicine.

ISSN 

0378-8741

Link 

http://dx.doi.org/10.1016/j.jep.2004.08.015

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)