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Title 

An isocoumarin with hepatoprotective activity in Hep G2 and primary hepatocytes from Agrimonia pilosa

Authors 

E J ParkHyuncheol OhT H KangD H SohnY C Kim

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2004

Citation 

Archives of Pharmacal Research, vol. 27, no. 9, pp. 944-946

Keywords 

agrimonia pilosaagrimonolidehepatoprotectiveisocoumarinrosaceaeplant extractagrimoniaanimalhumanisolation and purification

Abstract 

Phytochemical investigation of the aqueous extract of the roots of Agrimonia pilosa Ledeb. (Rosaceae), as guided by hepatoprotective activity in vitro, furnished two isocoumarins, agrimonolide (1) and agrimonolide 6-O-β-D-glucoside (3), and (+)-catechin (2). Compound 1 showed hepatoprotective effects on both tacrine-induced cytotoxicity in human liver-derived Hep G2 cells and tert-butyl hydroperoxide-induced cytotoxicity in rat primary hepatocytes with EC50 values of 88.2 ± 2.8 and 37.7 ± 1.6 μM, respectively.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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