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Title 

Isolation of angiotensin converting enzyme (ACE) inhibitory flavonoids from Sedum sarmentosum

Authors 

Hyuncheol OhD G KangJ W KwonT O KwonS Y LeeD B LeeH S Lee

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2004

Citation 

Biological & Pharmaceutical Bulletin, vol. 27, no. 12, pp. 2035-2037

Keywords 

angiotensin converting enzyme (ACE)inhibitorsedum sarmentosumflavonoidsedum sarmentosum extractcrassulaceaeisolation and purificationangiotensin-converting enzyme inhibitorsflavonoidssedum

Abstract 

Bioassay-guided fractionation of the EtOAc-soluble extract of Sedum sarmentosum afforded a new flavonoid, quercetin-3-O-α-(6?- caffeoylglucosyl-β-1,2-rhamnoside) (1), along with four known flavonoids, quercetin 3-O-α-(6?-p-coumaroylglucosyl-β-1,2-rhamnoside) (2), isorhamnetin-3-β-glucopyranoside (3), quercetin-3-β-glucopyranoside (4), and kaempferol-3-α-arabinopyranoside (5). Purification of these compounds was conducted with the application of various chromatographic methods. Compounds 1-5 inhibited angiotensin I converting enzyme (ACE) activity in a concentration-dependent manner. Compounds 1-5 had 50% inhibitory concentration values of 158.9±11.1 μM, 351.6±3.9 μM, 408.9±4.6 μM, 708.8±23.1 μM, and 392.8±13.4 μM.

ISSN 

0918-6158

Link 

http://dx.doi.org/10.1248/bpb.27.2035

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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