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Title 

Anti-complementary activity of triterpenoides from fruits of Zizyphus jujuba

Authors 

S M LeeJ G ParkY H LeeC G LeeByung Sun MinJung Hee KimHyeong Kyu Lee

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2004

Citation 

Biological & Pharmaceutical Bulletin, vol. 27, no. 11, pp. 1883-1886

Keywords 

anti-complementary activitycoumaroyl groupoleanane-type triterpenezizyphus jujubadrug activityfruit

Abstract 

In order to determine on the anti-complement activity of triterpenes, following eleven triterpenoides were isolated from the fruits of the Zizyphus jujuba MILL: ceanothane-type triterpenes: colubrinic acid (1), zizyberenalic acid (11); lupane-type triterpenes: alphitolic acid (2), 3-O-cis-p-coumaroyl alphitolic acid (3), 3-O-trans-p-coumaroyl alphitolic acid (4), betulinic acid (7), betulonic acid (9); and oleanane-type triterpenes: 3-O-cis-p-coumaroyl maslinic acid (5), 3-O-trans-p-coumaroyl maslinic acid (6), oleanolic acid (8), oleanonic acid (10). These compounds were examined for their anti-complement activity against the classical pathway of the complement system. Among them, compounds 5, 6, and 8 exhibited significant anti-complement activity with IC50 values of 101.4, 143.9, and 163.4 μM, respectively, whereas the ceanothane-type and the lupane-type triterpenes were inactive. This suggests that the oleanane-structure plays an important role in inhibiting the hemolytic activity of human serum against erythrocytes.

ISSN 

0918-6158

Link 

http://dx.doi.org/10.1248/bpb.27.1883

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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