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Title 

Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Terminalia chebula fruit

Authors 

M NaK BaeS S KangByung Sun MinJ K YooY KamiryoY SenooS YokooN Miwa

Publisher 

Wiley-Blackwell

Issue Date 

2004

Citation 

Phytotherapy Research, vol. 18, no. 9, pp. 737-741

Keywords 

combretaceaeoxidative stresssouthern blotstelomere lengthterminalia chebulaterminalia chebula extractcell agingfruitskin aging

Abstract 

The ethanol extract from the fruit of Terminalia chebula (Combretaceae) exhibited significant inhibitory activity on oxidative stress and the age-dependent shortening of the telomeric DNA length. In the peroxidation model using t-BuOOH, the T. chebula extract showed a notable cytoprotective effect on the HEK-N/F cells with 60.5 ± 3.8% at a concentration of 50 μg/ml. In addition, the T. chebula extract exhibited a significant cytoprotective effect against UVB-induced oxidative damage. The life-span of the HEK-N/F cells was elongated by 40% as a result of the continuous administration of 3 μg/ml of the T. chebula extract compared to that of the control. These observations were attributed to the inhibitory effect of the T. chebula extract on the age-dependent shortening of the telomere, length as shown by the Southern blots of the terminal restriction fragments (TRFs) of DNA extracted from subculture passages.

ISSN 

0951-418X

Link 

http://dx.doi.org/10.1002/ptr.1529

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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