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Title 

Furo-1,2-naphthoquinones from Crataegus pinnatifida with ICAM-1 expression inhibition activity

Authors 

Byung Sun MinH T T HuongJung Hee KimH J JunM K NaN H NamHyeong Kyu LeeK BaeS S Kang

Publisher 

Georg Thieme Verlag

Issue Date 

2004

Citation 

Planta Medica, vol. 70, no. 12, pp. 1166-1169

Keywords 

crataegus pinnatifidacrataequinone Acrataequinone Bfuro-1,2-naphthoquinoneICAM-1 inhibitory activityrosaceae11,12 dimethoxy 3,4 furo 1,2 naphthoquinone11,12 dimethoxy 5 hydroxy 3,4 furo 1,2 naphthoquinonecrataegus extractintercellular adhesion molecule 1

Abstract 

Two new furo-1,2-naphthoquinones, crataequinones A (1) and B (2), were isolated from the fruits of Crataegus pinnatifida. The structures of two new compounds were determined as 11,12-dimethoxy-3,4-furo-1,2-naphthoquinone (1) and 11,12-dimethoxy-5-hydroxy-3,4-furo-1,2-naphthoquinone (2) by spectroscopic analysis. The two compounds 1 and 2 showed significant inhibitory activity with IC50 values of 33 and 90 μM, respectively, against the expression of intercellular adhesion molecule-1 (ICAM-1).

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2004-835846

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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