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Title 

Triterpenoid from Tiarella polyphylla, regulation of type 1 procollagen and MMP-1 in ultraviolet irradiation of cultured old age human dermal fibroblasts

Authors 

H I MoonJoongku LeeO P ZeeJ H Chung

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2004

Citation 

Archives of Pharmacal Research, vol. 27, no. 10, pp. 1060-1064

Keywords 

3, 23-Dihydroxy-20(29)-lupen-27-oic acidMMP-1old age human dermal fibroblaststiarella polyphyllatype 1-procollagenultraviolet irradiationcollagen type 1interstitial collagenaseagedcells, cultured

Abstract 

Although many studies have been performed to elucidate the molecular consequences of ultraviolet irradiation, little is known about the effect of natural products. Ultraviolet irradiation is widely considered to be an environmental stress. Here we investigated the effect of 3,23-dihydroxy-20(29)- lupen-27-oic acid on the regulation of MMP-1 and type 1 procollagen in Ultraviolet irradiation of cultured old age human dermal fibroblasts. 3, 23-dihydroxy-20(29)-lupen-27-oic acid was isolated from Tiarella polyphylla D. Don (Saxifragaceae). Among them, 3, 23-dihydroxy-20(29)-lupen-27-oic acid induced the regulation of Type 1- procollagen and reduced the regulation of MMP-1 at the protein levels in a dose-dependent manner by ultraviolet irradiation. Taken together, our results suggest that 3, 23-dihydroxy-20(29)- lupen-27-oic acid plays an important role in the induction of Type 1-procollagen and reduction of MMP-1 by ultraviolet irradiation in old age human dermal fibroblasts.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/BF02975432

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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