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Title 

In vitro cytotoxicity of mokko lactone in human leukemia HL-60 cells: induction of apoptotic cell death by mitochondrial membrane potential collapse

Authors 

Y G YunHyuncheol OhG S OhH O PaeB M ChoiJ W KwonT O KwonS I JangH T Chung

Publisher 

Informa Healthcare

Issue Date 

2004

Citation 

Immunopharmacology and Immunotoxicology, vol. 26, no. 3, pp. 343-353

Keywords 

apoptosismitochondrial membrane potentialmokko lactonesaussurea lappadehydrocostus lactonelipocortin 5sesquiterpene lactone derivativecell nucleuscell strain HL 60

Abstract 

We studied the effect of mokko lactone (ML) isolated from the roots of Saussurea lappa (Compositae), a plant that is used for medicinal purposes in Korea, on the induction of apoptosis in human leukemia HL-60 cells. ML was cytotoxic to HL-60 cells, and this cytotoxic effect of ML appears to be attributable to its induction of apoptotic cell death, as ML induced nuclear morphologic changes and internucleosomal DNA fragmentation and increased the proportion of Annexin V-positive cells and the activity of caspase-3. Further studies revealed that the induction of apoptosis by ML was associated with the loss of mitochondrial membrane potential. Collectively, our results suggest that apoptosis induced by ML in HL-60 cells was executed by a collapse of mitochondrial membrane potential followed by the activation of caspase-3. This is the first report on the mechanism of apoptosis-inducing effect of ML.

ISSN 

0892-3973

Link 

http://dx.doi.org/10.1081/IPH-200026863

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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