상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Immunohistochemical study of the distribution of neuronal voltage-gated calcium channels in the nNOS knock-out mouse cerebellum

Authors 

M J KimY H ChungK M JooGoo Taeg OhJ KimB LeeC I Cha

Publisher 

Elsevier

Issue Date 

2004

Citation 

Neuroscience Letters, vol. 369, no. 1, pp. 39-43

Keywords 

calcium channel subunitcerebellumimmunohistochemistryneuronal NO synthase (nNOS) knock-out (-/-) micenitric oxide (NO)neuronal nitric oxide synthasevoltage gated calcium channelcerebellum cortexcerebellum nucleuscontrolled study

Abstract 

Nitric oxide (NO) participates in synaptic plasticity, neuronal development, and apoptosis. The involvement of NO and ionic calcium in synaptic plasticity imply that NO may exert an effect on Ca2+ channels. Therefore, we investigated changes in the expressions of calcium channel subunits (Cav1.2/α1C, Cav1.3/ α1D, Cav2.1/α1A, and Ca v2.2/α1B) in nNOS knock-out (-/-) (nNOS (-/-)) mouse cerebellum using an immunohistochemical approach. We found that the immunoreactivities of the Cav1.2 and Cav1.3 subunits were reduced in the cell bodies of Purkinje cells in these mice and that the signal of the Cav1.2 subunit in neurons and of the Ca v1.3 subunit in the neuropils of nNOS(-/-) mice cerebellar nuclei were significantly down-regulated. We show, for the first time, that prolonged NO deficiency in the cerebellum may affect calcium channel protein expressions, especially, of the Cav1.2 and Cav1.3 subunits.

ISSN 

0304-3940

Link 

http://dx.doi.org/10.1016/j.neulet.2004.07.047

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)