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Title 

Isoterreulactone A, a novel meroterpenoid with anti-acetylcholinesterase activity produced by Aspergillus terreus

Authors 

Ick Dong YooKyung Mi ChoC K LeeWon Gon Kim

Publisher 

Elsevier

Issue Date 

2005

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 15, no. 2, pp. 353-356

Keywords 

anti-acetylcholinesterasemeroterpenoidacetylcholinesterasecholinesteraseisoterreulactone alactone derivativeterpenoid derivativeterreulactoneunclassified drugaspergillus terreus

Abstract 

A new seven-membered lactone type meroterpenoid, isoterreulactone A, was isolated from the solid state fermentation of Aspergillus terreus and its structure was established by various spectral analysis. Isoterreulactone A inhibited acetylcholinesterase with an IC50 value of 2.5 μM while did not inhibit butyrylcholinesterase even at 500 μM. A new seven-membered lactone type meroterpenoid, isoterreulactone A, was isolated from the solid state fermentation of Aspergillus terreus and its structure was established by various spectral analysis. Isoterreulactone A inhibited acetylcholinesterase with an IC50 value of 2.5 μM while did not inhibit butyrylcholinesterase even at 500 μM.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2004.10.067

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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